Same rules apply that would be used for personal amounts.
When ordering bulk, make sure to mix your bitcoins after you purchase them.
Wherever you send it to, ensure that the address is clean. The last thing you want to do is send 1000tabs of acid to an address that has a couple ounces of weed, an eightball of coke, 100+ xannies... even if they are always hidden. If you decide to order bulk to an address that is "dirty"... good luck. The vast majority of packages sent do go through, but this is about improving your chances of not getting caught.
The address really is the most important detail if you ask me. If you have an address that is potentially sketchy... i wouldnt do it.
Its highly encouraged to use Tails or a privacy minded OS that strictly uses ToR for ordering. Some people would say to use public wifi to order but i personally wouldnt.
Shop around!! Look for great prices!! And do as much research as you can on the vendor you choose. I can get acid for 1.5$/per bulk rate when there is a solid supply. But if i was lazy, sometimes the best bulk rate is around 2-3 per on some markets.
Some drugs are much easier to order bulk. Weed? The most difficult imo. Acid? One of the easiest (along with RCs,blottered drugs that dont smell etc). Know if your product could be smelly. I personally wouldnt order bulk of smelly soykaf.
The more people who know that you order soykaf, the weaker your opsec in general. You will probably want to tell all of your friends. For your sake and theirs, shut your fuarrrking mouth.
Im assuming youre reselling. Make sure you know everything you can know about your product, and be sure to pass along any information that is relevant to your customers (dosages, strength of the soykaf, where its from, etc). You should tell them whats important, especially if they ask.
Do not record what you do. Ever. Find mostly foolproof ways to communicate-a phone call telling someone you can plug them is a recorded admittance of guilt that stays in a database somewhere for quite some time. Maybe get a burner?
Good luck and ask any questions you have, ill answer to the best of my ability